Anti-hypoxia therapy — mechanism of action
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It is sometimes expedient to combine 2D and 3D techniques to visualize complex biological processes. 3D modeling and animation can create detailed, scientifically accurate anatomical and molecular models, while schemes animated in 2D are more clear when explaining biochemical processes. Visual Science’s video about anti-hypoxia therapy is an example of an effective combination of 2D and 3D in one project.

Hypoxia — low tissue oxygen level — is linked to the development of many pathological conditions in the human body. The disruption of energy production in cells is one of the key links in the pathogenesis of common illnesses, from ischemic heart disease, arterial hypertension and diabetes, to age-related neurodegenerative diseases, ophthalmopathies and musculoskeletal disorders. Most energy-generating processes in cells are localized in the mitochondria, whose functions require a normal oxygen concentration in the tissue. Hypoxia disrupts the citric acid cycle and ATP synthesis in mitochondria, leading to a number of negative consequences, from dysfunctions in the membrane channels to the degradation of cellular structures due to an excess of free radicals.

Some mitochondrial substrates might have the potential to stabilize the work of individual reactions in the Krebs cycle, thus reducing the negative consequences of low oxygen level in the cells. This effect is used in the development of the anti-hypoxia therapy presented in Visual Science animation.

In this version of animation, all mentions of the drug’s name are cut out to avoid violating the laws on prescription drug advertising.

Congratulation for your very succesful 3D HIV model
Prof. Françoise BARRÉ-SINOUSSI
Nobel Prize in Medicine 2008, Pasteur Institute, Paris, France